The Collegeville region is defined by the areas served by the Collegeville Post Office. The Post Office, zip code 19426, is located in the Borough of Collegeville. The region is made up of: the Borough of Collegeville, the Borough of Trappe, and portions of Upper Providence, Lower Providence, Perkiomen, Skippack, and Worcester townships. For more information, view the links on the left.

Another interpretation of Collegeville centers around the Pharmaceutical Corporate centers and the Providence Town Center Shopping Center located a few miles from the Borough at the Rt. 422 and Rt. 29 interchange. The pharmaceuticals companies and the stores located at the Providence Town Center have Collegeville mailing addresses and the interchange - while serving Phoenixville as well as Collegeville - is referred to in news and traffic reports as Collegeville. When defined this way, Collegeville would include portions of the Phoenixville, Royersford, Limerick, Oaks, and Audubon regions.